Innovation Labo Spain and Miguel Hernández Institute reveal the world's first organic, naturally fermented urolithin.

Innovation Labo Spain and Japan, in collaboration with the Miguel Hernández Institute in Spain, today announced a scientific milestone in longevity nutrition: the development of the world’s first organically cultivated pomegranate capable of naturally generating a full spectrum of urolithins through a controlled fermentation process. This non-GMO innovation represents a significant advancement in food-based mitochondrial health, addressing a fundamental limitation in conventional urolithin supplementation.

Urolithins, bioactive metabolites produced from ellagitannins, are widely recognized for their significant role in mitochondrial function, cellular renewal, and healthy aging. However, due to variations in gut microbiome composition, many individuals struggle to efficiently convert dietary polyphenols into urolithins. Innovation Labo’s innovative approach bypasses this biological limitation by delivering pre-formed, naturally derived urolithins in a format that is specifically aligned with human metabolic pathways. This ensures more effective absorption and utilization of urolithins, offering a more reliable and accessible solution for supporting mitochondrial health and promoting healthy aging.

A New Biological Pathway to Full-Spectrum Urolithins

The innovation begins in a certified organic, biodynamic pomegranate plantation in southern Spain, where extreme heat, intense solar exposure, and environmental stressors naturally drive the accumulation of high polyphenol levels and foster a diverse native microbiome.

Innovation Labo’s proprietary controlled fermentation technology transforms the ellagitannins from the pomegranate fruit into a naturally occurring, full-spectrum urolithin complex, including Urolithins A, B, C, and D. This diverse metabolite profile closely mirrors the natural variety produced by a healthy human gut microbiome, offering a more comprehensive and biologically relevant solution than isolated or synthetic single-molecule alternatives. By providing a full spectrum of urolithins, this approach ensures the ingredient works in harmony with human metabolism, promoting more effective and holistic mitochondrial health and overall well-being.

Why Full-Spectrum Urolithins Matter

Urolithin A is widely recognized for its role in activating mitophagy—the cellular process responsible for clearing damaged mitochondria and supporting mitochondrial renewal. Emerging scientific evidence, however, highlights the complementary roles of other naturally occurring urolithins:

• Urolithin A – supports mitophagy and mitochondrial regeneration

• Urolithin B – contributes to muscle maintenance and anti-inflammatory pathways

• Urolithins C & D – provide additional antioxidant and metabolic-regulatory support

Delivering these metabolites as a full-spectrum complex offers a more comprehensive approach to mitochondrial optimization, reflecting how ellagitannins are metabolized in nature rather than reduced to a single isolated compound.

ADS™ Natural Delivery Architecture for Enhanced Absorption

During fermentation, the pomegranate matrix naturally forms plant-derived nanovesicles, which make up Innovation Labo’s proprietary ADS™ (Advanced Delivery System). These vesicles form a unique delivery mechanism that significantly enhances the metabolite absorption and bioavailability in the intestines.

ADS™ is entirely plant-derived and clean-label, requiring no synthetic excipients, chemical solvents, or artificial encapsulation technologies. This natural delivery architecture supports improved bioavailability while preserving the integrity of the fermented pomegranate metabolome.

A New Standard for Clean-Label Longevity Science“This project demonstrates the extraordinary potential unlocked when biodynamic agriculture and microbiome science converge,” Dr. Vicente Micol Molina, the Research Director, said. “Producing full-spectrum urolithins directly from organically grown pomegranates represents a transformative step toward accessible, food-based mitochondrial health.”As global interest in validated longevity solutions continues to grow, Innovation Labo’s naturally fermented, full-spectrum urolithin complex sets a new standard for clean-label, science-backed nutraceutical innovation. This cutting-edge ingredient is designed with scalability, sustainability, and clinical relevance in mind, providing formulators and brands with a next-generation foundation for promoting mitochondrial health, supporting cellular renewal, and advancing healthy aging. It represents a significant step forward in longevity science, meeting consumer demand for effective, natural health solutions.